An overview of tuberculosis chemotherapy a literature review

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For the last 50 years, no new anti-TB drug has been discovered. This literature review provides a brief discussion of existing drugs and emerging drug targets, and also of the advantages of incorporating modern drug delivery systems and immune modulators in order to improve the existing treatment regimen in terms of better efficacy, reduced drug administration frequency, shortened period of treatment and reduced drug related toxicity. However, owing to the enormous cost and time involved in new drug development, improvement of the existing treatment regimen is seen to be a valid alternative. The bacteria involved is a member of Mycobacterium family which has over 60 species with only a few like Mycobacterium tuberculosis Mtb , Mycobacterium leprae, Mycobacterium africanum and Mycobacterium avium that cause human diseases. Mtb can exist in the human body for a long time without showing any clinical symptoms; this phase is called the latent stage. Once the hosts immune system becomes weakened, either because of age or concurrent disease, the bacteria attain virulent or turn to the active form.
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LITERATURE REVIEW OF TUBERCULOSIS

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Tuberculosis - Symptoms and causes - Mayo Clinic

For the last 50 years, no new anti-TB drug has been discovered. This literature review provides a brief discussion of existing drugs and emerging drug targets, and also of the advantages of incorporating modern drug delivery systems and immune modulators in order to improve the existing treatment regimen in terms of better efficacy, reduced drug administration frequency, shortened period of treatment and reduced drug related toxicity. However, owing to the enormous cost and time involved in new drug development, improvement of the existing treatment regimen is seen to be a valid alternative. Documents: Advanced Search Include Citations. Authors: Advanced Search Include Citations. Venue: J. Keyphrases tuberculosis chemotherapy literature review treatment regimen enormous cost drug resistant new anti-tb drug immune modulators reduced drug literature review human immunodeficiency virus brief discussion modern drug delivery system major global health threat abstract tuberculosis drug target new drug target valid alternative post-publication review drug administration frequency vital challenge registered reader multi drug resistant new drug development.
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An Overview of Tuberculosis Chemotherapy – a Literature Review

Tuberculosis TB is a potentially serious infectious disease that mainly affects the lungs. The bacteria that cause tuberculosis are spread from person to person through tiny droplets released into the air via coughs and sneezes. Once rare in developed countries, tuberculosis infections began increasing in , partly because of the emergence of HIV, the virus that causes AIDS.
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